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11/19/2008
Wednesday morning
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| >>> Gunisha Singh is a 46 year old Indian female with no significant past >>> medical history who presents for evaluation of a newly diagnosed right-sided >>> pleural malignant mesothelioma. >>> Mrs. Singh was in her usual excellent state of health until >>> approximately January 1996 when she noticed the onset of right neck, arm, >>> and shoulder discomfort gradually increasing in intensity. This was often >>> accompanied by a burning sensation in the distal arm and fingers on the >>> right side. At that time she was living in Hong Kong and was evaluated by a >>> neurosurgeon who felt that her symptoms were consistent with two herniated >>> cervical discs. The patient then came to the U.S. for evaluation by a >>> neurosurgeon at the University of California in San Francisco who felt that >>> she had cervical spondylosis with herniated disc. |
| >Carbone was puzzled. Mesothelioma is a rare cancer. Few human cases were >reported before the 1950s, but its incidence had been increasing steadily, >reaching several thousand cases a year in the United States by 1988. This parallels, with a delay, the rise in use of tobacco, a strong carcinogen, and the exposure of persons to second-hand smoke. |
| 1964 * Dr. Irving Selikoff publishes a study of asbestos workers in the Journal of the American Medical Association, proving that people who work with asbestos-containing materials have an abnormal incidence of asbestosis, lung cancer, and mesothelioma. Barry I. Castleman, Asbestos: Medical and Legal Aspects, 4th edition, Aspen Law and Business, Englewood Cliffs, NJ 1996, p.126 |
| >Carbone decided to use PCR to test 48 human mesotheliomas stored at the >NIH. He was stunned: 28 of them contained SV40. And the other 20? |
| >>>>> Gunisha Singh is a 46 year old Indian female with no significant >>past >>>>> medical history who presents for evaluation of a newly diagnosed >>right-sided >>>>> pleural malignant mesothelioma. >>>>> Mrs. Singh was in her usual excellent state of health until >>>>> approximately January 1996 when she noticed the onset of right >>neck, arm, >>>>> and shoulder discomfort gradually increasing in intensity. This was >>often >>>>> accompanied by a burning sensation in the distal arm and fingers on >>the >>>>> right side. At that time she was living in Hong Kong and was >>evaluated by >>a >>>>> neurosurgeon who felt that her symptoms were consistent with two >>herniated >>>>> cervical discs. The patient then came to the U.S. for evaluation by &. |
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