11/19/2008
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>>> Gunisha Singh is a 46 year old Indian female with no significant past >>> medical history who presents for evaluation of a newly diagnosed right-sided >>> pleural malignant mesothelioma. >>>         Mrs. Singh was in her usual excellent state of health until >>> approximately January 1996 when she noticed the onset of right neck, arm, >>> and shoulder discomfort gradually increasing in intensity. This was often >>> accompanied by a burning sensation in the distal arm and fingers on the >>> right side. At that time she was living in Hong Kong and was evaluated by a >>> neurosurgeon who felt that her symptoms were consistent with two herniated >>> cervical discs. The patient then came to the U.S. for evaluation by a >>> neurosurgeon at the University of California in San Francisco who felt that >>> she had cervical spondylosis with herniated disc.
>Carbone was puzzled. Mesothelioma is a rare cancer. Few human cases were >reported before the 1950s, but its incidence had been increasing steadily, >reaching several thousand cases a year in the United States by 1988.   This parallels, with a delay, the rise in use of tobacco, a strong carcinogen, and the exposure of persons to second-hand smoke.
1964 * Dr. Irving Selikoff publishes a study of asbestos workers in the Journal of the American Medical Association, proving that people who work with asbestos-containing materials have an abnormal incidence of asbestosis, lung cancer, and mesothelioma. Barry I. Castleman, Asbestos: Medical and Legal Aspects, 4th edition, Aspen Law and Business, Englewood Cliffs, NJ 1996, p.126
>Carbone decided to use PCR to test 48 human mesotheliomas stored at the >NIH. He was stunned: 28 of them contained SV40.   And the other 20?
- Hide quoted text -- Show quoted text ->>>         My mom, Gunisha Singh, was diagnosed about a month ago with >>> cancer--she has malignant mesothelioma, which is cancer of the inner chest >>> cavity. This is a rare and mostly incurable form of cancer. Standard >>> treatment like chemotherapy and radiation therapy is not very effective >>> against it, and by the time her particular cancer was diagnosed it was >>> judged inoperable by Dr. M.S. Bains of the Memorial Sloane-Kettering Cancer >>> Center in New York City. >>>         As far as we know, the only treatment that can potentially cure her >>> is gene-therapy. Gene-therapy is on the cutting edge of cancer treatment; >>> basically what doctors do is take an ordinary virus like the cold virus, >>> fill it with "suicide genes" that will cause the cancer cells to >>>.
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