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1/8/2009
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| AIM AND BACKGROUND: To evaluate the characteristics of a case-series
of 79 malignant mesothelioma patients collected
from the main teaching hospital of Rome, Italy, and other local
clinics of Latium Region and to assess the role of asbestos
exposure, since previous studies on the occurrence of the disease in
this area were lacking. METHODS: The study included
cytohistologically diagnosed malignant mesothelioma (71 pleural, 7
peritoneal, and 1 testicular tunica lis) detected or
referred for consultation during the period 1980-1995. Information
regarding occupational and/or nonoccupational exposures
was derived from clinical records and interviews, when available.
RESULTS: Patients were resident in Rome and other towns
of Latium; a few were from other parts of central and southern Italy.
Exposure to asbestos was assessed for 45.5% of patients,
another 45.5% had unknown exposure, and for the remaining 9% such
info. |
| The authors briefly reviewed the literature concerning the risk
factors for primary pleural tumors in humans. The results from the
most relevant studies emphasize the fact that the large majority of
mesotheliomas are associated with exposure to asbestos or
asbestiform fibers. Exposure to asbestos is mainly through industrial
use, and mesotheliomas result from occupational,
para-occupational, or environmental exposure. Fibers of crocidolite,
amosite, and chrysotile appear to be, in descending order,
more carcinogenic for pleural tissues. The authors summarize the
available data on consumption of asbestos and
asbestos-based products in Italy. The chrysotile-asbestos mine in
Balangero (Piedmont) stimulated the industrial production of
asbestos-cement; asbestos has been largely sprayed among shipyards
and user for insulating railroad coaches and carriages.
Italy had the greatest consumption of crocidolite in Europe, whi. |
| In order to provide estimates of the accuracy of death certification
of malignant pleural mesothelioma in Italy, the causes of
death of a series of ascertained cases were investigated. The study
included 523 cases of pleural mesothelioma diagnosed in
1984-1988 by 88 hospital departments and clinics. Vital status at 7
May 1990 was ascertained for 92.7% of subjects. The
overall concordance between pathological diagnosis and death
certification was about 75%.
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Med Lav 1994 Mar-Apr;85(2):157-60 |
| Latency periods (time intervals elapsing between first exposure to
asbestos and death) were examined in 421 cases of
malignant pleural mesothelioma, diagnosed in the Trieste-Monfalcone
area, Italy. Occupational data were collected from the
patients or from their relatives by personal or telephone interviews.
Routine lung sections were examined for asbestos bodies in
370 cases. Latency periods, calculated in 312 cases, ranged from 14
to 72 years (mean 48.7, median 51). Latency periods
differed significantly from one occupational group to another. Mean
latency periods were 29.6 among insulators, 35.4 among
dock workers, 43.7 in a heterogeneous group defined as various, 46.4
in non-shipbuilding industry workers, 49.4 in shipyard
workers, 51.7 among women with a history of domestic exposure to
asbestos, and 56.2 in people employed in maritime
trades. The ANOVA test indicated a correlation between latency
periods an. |
| All cases of pleural malignant mesothelioma occurring in Tuscany were
collected, backdated to 1980 (to 1970 for the
provinces of Florence and Prato; to 1975 for the provinces of Pisa
and Siena), in order to evaluate the incidence of
occupational exposure to asbestos. The aim was to enhance primary
prevention in those workplaces still at risk nowadays. To
achieve information on the possible occupational, domestic or
environmental exposure, an interview was conducted using a
semi-structured questionnaire. An exposure classification was
produced to focus preventive intervention. This surveillance
system needs to be developed to contribute to epidemiological
research, especially on the effects of low level exposures, and to
primary prevention.
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Med Lav 1997 Jul-Aug;88(4):302-9 |
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