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1/8/2009
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| A series of 421 malignant pleural mesotheliomas, diagnosed in the
Trieste-Monfalcone area, northeastern Italy, were reviewed.
A large majority of the patients had been employed in naval work
(shipbuilding, maritime trades, and dock work). Latency
periods (time intervals between first exposure to asbestos and
death), showed wide variations from one occupational category
to another. Such variations were attributable, but only partly, to
differences in the intensity of the exposure to asbestos. Various
family cases were identified, including people with and without blood
relationships. The data, obtained in the studies on
Trieste-Monfalcone mesothelioma, suggest that interactions between
asbestos and other factors play a considerable role in the
pathogenesis of asbestos-related mesothelioma.
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Med Lav 1997 Jul-Aug;88(4):310-5 |
| We reviewed the certificates of 39,650 deaths which occurred in the
period 1975-1988 in Leghorn and of 45,900 in La Spezia
(Italy) in the period 1958-1988. In total 262 cases have been
recorded as pleural mesothelioma. The main occupational
exposures occurred in the shipbuilding industry. Regarding
non-occupational exposures to asbestos, 13 cases of mesothelioma
were found in women who had washed the work clothes of their
relatives at home; we also found other domestic uses of
asbestos which were rarely or never discussed previously in the
literature: six cases might be explained by the installation of
fireproof or non-conductive materials in the domestic environment.
These exposures probably are more frequent than realized until now.
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Am J Ind Med 1992;21(4):577-85 |
| All cases of pleural malignant mesothelioma occurring in Tuscany were
collected, backdated to 1980 (to 1970 for the
provinces of Florence and Prato; to 1975 for the provinces of Pisa
and Siena), in order to evaluate the incidence of
occupational exposure to asbestos. The aim was to enhance primary
prevention in those workplaces still at risk nowadays. To
achieve information on the possible occupational, domestic or
environmental exposure, an interview was conducted using a
semi-structured questionnaire. An exposure classification was
produced to focus preventive intervention. This surveillance
system needs to be developed to contribute to epidemiological
research, especially on the effects of low level exposures, and to
primary prevention.
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Med Lav 1997 Jul-Aug;88(4):302-9 |
| One hundred and seventy malignant pleural mesotheliomas seen at
necropsy at the Institute of Pathological Anatomy of the
Trieste University during the period 1968-1987 were reviewed. The
series included 153 men and 17 women, aged between 33
and 92 years (median 70 years). Lifetime work histories were obtained
from the patients relatives by personal or telephone
interviews in 162 cases. A majority of the male subjects had been
employed in naval work, 99 people having worked in the
ship-building industry, 19 in the navy and merchant marine, and 7 in
docks. A variety of trades appeared in the remaining
histories. Work histories were indicative of occupational exposure to
asbestos in 150 cases. A further 5 patients with negative
or insufficient data showed asbestos bodies in routine lung sections
and 5 women had a history of domestic exposure. A
majority of the patients had had their first exposure before 1950.
The. |
| In stating that a threshold of effect has never been found for asbestos, Rall
stands behind the outdated one fiber can kill theory of carcinogenesis.
However, Rall fails to mention data supporting a threshold for chrysotile in
lung cancer (11, asbestosis (12), and mesothelioma (13) as well as a panel
report from the Health Effects Institute-Asbestos Research (HEI-AR) detailing
animal and in vitro dose-response studies exhibiting no-observed adverse effect
levels (NOAELs) for asbestos (14). Our recent work documents a dose-dependent
increase in asbestos-induced proto-oncogene activation in mesothelial cells with
no induction at lowest concentrations of fibers tested and an enhanced potency
of crocidolite asbestos in comparison to chrysotile (15). |
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