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1/8/2009
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| AIM AND BACKGROUND: To evaluate the characteristics of a case-series
of 79 malignant mesothelioma patients collected
from the main teaching hospital of Rome, Italy, and other local
clinics of Latium Region and to assess the role of asbestos
exposure, since previous studies on the occurrence of the disease in
this area were lacking. METHODS: The study included
cytohistologically diagnosed malignant mesothelioma (71 pleural, 7
peritoneal, and 1 testicular tunica lis) detected or
referred for consultation during the period 1980-1995. Information
regarding occupational and/or nonoccupational exposures
was derived from clinical records and interviews, when available.
RESULTS: Patients were resident in Rome and other towns
of Latium; a few were from other parts of central and southern Italy.
Exposure to asbestos was assessed for 45.5% of patients,
another 45.5% had unknown exposure, and for the remaining 9% such
info. |
| The authors briefly reviewed the literature concerning the risk
factors for primary pleural tumors in humans. The results from the
most relevant studies emphasize the fact that the large majority of
mesotheliomas are associated with exposure to asbestos or
asbestiform fibers. Exposure to asbestos is mainly through industrial
use, and mesotheliomas result from occupational,
para-occupational, or environmental exposure. Fibers of crocidolite,
amosite, and chrysotile appear to be, in descending order,
more carcinogenic for pleural tissues. The authors summarize the
available data on consumption of asbestos and
asbestos-based products in Italy. The chrysotile-asbestos mine in
Balangero (Piedmont) stimulated the industrial production of
asbestos-cement; asbestos has been largely sprayed among shipyards
and user for insulating railroad coaches and carriages.
Italy had the greatest consumption of crocidolite in Europe, whi. |
| The analysis of 335 cases of mesothelioma observed at the Ramazzini
Foundation and the Bologna Institute of Oncology has
shown: 1) a high percentage of correlation of these tumours with
asbestos exposure; 2) a large number of population categories
potentially exposed to asbestos fibres and therefore at risk of
developing mesothelioma; and 3) the high risk of mesothelioma
among people exposed in various circumstances to asbestos used in
railroads and sugar refinery plants.
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Med Lav 1997 Jul-Aug;88(4):316-20 |
| We reviewed the certificates of 39,650 deaths which occurred in the
period 1975-1988 in Leghorn and of 45,900 in La Spezia
(Italy) in the period 1958-1988. In total 262 cases have been
recorded as pleural mesothelioma. The main occupational
exposures occurred in the shipbuilding industry. Regarding
non-occupational exposures to asbestos, 13 cases of mesothelioma
were found in women who had washed the work clothes of their
relatives at home; we also found other domestic uses of
asbestos which were rarely or never discussed previously in the
literature: six cases might be explained by the installation of
fireproof or non-conductive materials in the domestic environment.
These exposures probably are more frequent than realized until now.
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Am J Ind Med 1992;21(4):577-85 |
| Our 1990 article reported on recent papers in the peer-reviewed literature and
two international symposia, one at the International Agency for Research on
Cancer (2) and the other at Harvard University (3), all concluding that
chrysotile fibers are less active than amphibole types (crocidolite, amosite,
tremolite) of asbestos in the causation of mesothelioma in man. In his summary
of the IARC meeting, Sir Richard Doll, an eminent epidemiologist, concluded
there is the difference between the effects of chrysotile and amphiboles, which
is so great in relation to mesothelioma that it is possible to argue that
chrysotile does not cause mesothelioma at all (2). This observation has been
supported by numerous peer-reviewed papers and working groups subsequently
(4-6). |
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