 |
1/8/2009
Thursday morning
This topic is closed off and you will be taken directly to the website.
Topics taken from open source list. I hope you find this useful.
This site is for our clients only as an information resource.
| In stating that a threshold of effect has never been found for asbestos, Rall
stands behind the outdated one fiber can kill theory of carcinogenesis.
However, Rall fails to mention data supporting a threshold for chrysotile in
lung cancer (11, asbestosis (12), and mesothelioma (13) as well as a panel
report from the Health Effects Institute-Asbestos Research (HEI-AR) detailing
animal and in vitro dose-response studies exhibiting no-observed adverse effect
levels (NOAELs) for asbestos (14). Our recent work documents a dose-dependent
increase in asbestos-induced proto-oncogene activation in mesothelial cells with
no induction at lowest concentrations of fibers tested and an enhanced potency
of crocidolite asbestos in comparison to chrysotile (15). |
| Dr. Finkelstein also cited five cases of mesothelioma among former
Holmes workers. Three of the five workers died at less than fifty years
of age and all were less than sixty years old! |
| The analysis of 335 cases of mesothelioma observed at the Ramazzini
Foundation and the Bologna Institute of Oncology has
shown: 1) a high percentage of correlation of these tumours with
asbestos exposure; 2) a large number of population categories
potentially exposed to asbestos fibres and therefore at risk of
developing mesothelioma; and 3) the high risk of mesothelioma
among people exposed in various circumstances to asbestos used in
railroads and sugar refinery plants.
______________________________________________________
Med Lav 1997 Jul-Aug;88(4):316-20 |
| Following the finding of an unexpected cluster of mesotheliomas in
textile workers, a surveillance system of malignant
mesotheliomas was implemented in the region of Tuscany, Italy. This
article reports on the investigation of 124 cases of
mesothelioma diagnosed and reviewed by the Institutes of Morbid
Anatomy and Histopathology at the Universities of Florence,
Pisa, and Siena between 1970 and 1988. A complete occupational and
asbestos exposure history was assessed through a
semi-structured questionnaire directly administered to resident cases
of Tuscany or, if deceased, to their closest living relatives,
for a total of 100 interviews. The hypothesis of past occupational
asbestos exposure was verified and documented.
Seventy-two cases have been classified as occupationally exposed to
asbestos; four were classified in the category of possible
domestic exposure to asbestos. For two others, the role of other
risk . |
| Our 1990 article reported on recent papers in the peer-reviewed literature and
two international symposia, one at the International Agency for Research on
Cancer (2) and the other at Harvard University (3), all concluding that
chrysotile fibers are less active than amphibole types (crocidolite, amosite,
tremolite) of asbestos in the causation of mesothelioma in man. In his summary
of the IARC meeting, Sir Richard Doll, an eminent epidemiologist, concluded
there is the difference between the effects of chrysotile and amphiboles, which
is so great in relation to mesothelioma that it is possible to argue that
chrysotile does not cause mesothelioma at all (2). This observation has been
supported by numerous peer-reviewed papers and working groups subsequently
(4-6). |
|
