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1/8/2009
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| A case-control study on pleural malignant mesothelioma (MM) was
conducted in Casale Monferrato, where the largest Italian
asbestos cement (AC) factory had been operating from 1907 to 1985. In
a previous study we observed a five to seven-fold
increase in the incidence of MM among people living in that city and
never employed in the factory mentioned. The present
study includes cases of MM with histological diagnosis over the
period 1.1.1987-30.6.1993 among residents in the Local
Health Unit (LHU) of Casale Monferrato. Population controls were
randomly extracted from the list of the residents in the
LHU, matched to cases on , date of birth, vital status and date of
death. Cases and controls (or their closest relative) were
interviewed with a standardised questionnaire focusing on asbestos
exposure in the (life-long) residential and occupational
histories and in leisure time activities as well as on occupational
a. |
| One hundred and seventy malignant pleural mesotheliomas seen at
necropsy at the Institute of Pathological Anatomy of the
Trieste University during the period 1968-1987 were reviewed. The
series included 153 men and 17 women, aged between 33
and 92 years (median 70 years). Lifetime work histories were obtained
from the patients relatives by personal or telephone
interviews in 162 cases. A majority of the male subjects had been
employed in naval work, 99 people having worked in the
ship-building industry, 19 in the navy and merchant marine, and 7 in
docks. A variety of trades appeared in the remaining
histories. Work histories were indicative of occupational exposure to
asbestos in 150 cases. A further 5 patients with negative
or insufficient data showed asbestos bodies in routine lung sections
and 5 women had a history of domestic exposure. A
majority of the patients had had their first exposure before 1950.
The. |
| AIM AND BACKGROUND: To evaluate the characteristics of a case-series
of 79 malignant mesothelioma patients collected
from the main teaching hospital of Rome, Italy, and other local
clinics of Latium Region and to assess the role of asbestos
exposure, since previous studies on the occurrence of the disease in
this area were lacking. METHODS: The study included
cytohistologically diagnosed malignant mesothelioma (71 pleural, 7
peritoneal, and 1 testicular tunica lis) detected or
referred for consultation during the period 1980-1995. Information
regarding occupational and/or nonoccupational exposures
was derived from clinical records and interviews, when available.
RESULTS: Patients were resident in Rome and other towns
of Latium; a few were from other parts of central and southern Italy.
Exposure to asbestos was assessed for 45.5% of patients,
another 45.5% had unknown exposure, and for the remaining 9% such
info. |
| Latency periods (time intervals elapsing between first exposure to
asbestos and death) were examined in 421 cases of
malignant pleural mesothelioma, diagnosed in the Trieste-Monfalcone
area, Italy. Occupational data were collected from the
patients or from their relatives by personal or telephone interviews.
Routine lung sections were examined for asbestos bodies in
370 cases. Latency periods, calculated in 312 cases, ranged from 14
to 72 years (mean 48.7, median 51). Latency periods
differed significantly from one occupational group to another. Mean
latency periods were 29.6 among insulators, 35.4 among
dock workers, 43.7 in a heterogeneous group defined as various, 46.4
in non-shipbuilding industry workers, 49.4 in shipyard
workers, 51.7 among women with a history of domestic exposure to
asbestos, and 56.2 in people employed in maritime
trades. The ANOVA test indicated a correlation between latency
periods an. |
| A series of 421 malignant pleural mesotheliomas, diagnosed in the
Trieste-Monfalcone area, northeastern Italy, were reviewed.
A large majority of the patients had been employed in naval work
(shipbuilding, maritime trades, and dock work). Latency
periods (time intervals between first exposure to asbestos and
death), showed wide variations from one occupational category
to another. Such variations were attributable, but only partly, to
differences in the intensity of the exposure to asbestos. Various
family cases were identified, including people with and without blood
relationships. The data, obtained in the studies on
Trieste-Monfalcone mesothelioma, suggest that interactions between
asbestos and other factors play a considerable role in the
pathogenesis of asbestos-related mesothelioma.
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Med Lav 1997 Jul-Aug;88(4):310-5 |
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