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1/8/2009
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| All cases of pleural malignant mesothelioma occurring in Tuscany were
collected, backdated to 1980 (to 1970 for the
provinces of Florence and Prato; to 1975 for the provinces of Pisa
and Siena), in order to evaluate the incidence of
occupational exposure to asbestos. The aim was to enhance primary
prevention in those workplaces still at risk nowadays. To
achieve information on the possible occupational, domestic or
environmental exposure, an interview was conducted using a
semi-structured questionnaire. An exposure classification was
produced to focus preventive intervention. This surveillance
system needs to be developed to contribute to epidemiological
research, especially on the effects of low level exposures, and to
primary prevention.
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Med Lav 1997 Jul-Aug;88(4):302-9 |
| Following the finding of an unexpected cluster of mesotheliomas in
textile workers, a surveillance system of malignant
mesotheliomas was implemented in the region of Tuscany, Italy. This
article reports on the investigation of 124 cases of
mesothelioma diagnosed and reviewed by the Institutes of Morbid
Anatomy and Histopathology at the Universities of Florence,
Pisa, and Siena between 1970 and 1988. A complete occupational and
asbestos exposure history was assessed through a
semi-structured questionnaire directly administered to resident cases
of Tuscany or, if deceased, to their closest living relatives,
for a total of 100 interviews. The hypothesis of past occupational
asbestos exposure was verified and documented.
Seventy-two cases have been classified as occupationally exposed to
asbestos; four were classified in the category of possible
domestic exposure to asbestos. For two others, the role of other
risk . |
| A case-control study on pleural malignant mesothelioma (MM) was
conducted in Casale Monferrato, where the largest Italian
asbestos cement (AC) factory had been operating from 1907 to 1985. In
a previous study we observed a five to seven-fold
increase in the incidence of MM among people living in that city and
never employed in the factory mentioned. The present
study includes cases of MM with histological diagnosis over the
period 1.1.1987-30.6.1993 among residents in the Local
Health Unit (LHU) of Casale Monferrato. Population controls were
randomly extracted from the list of the residents in the
LHU, matched to cases on , date of birth, vital status and date of
death. Cases and controls (or their closest relative) were
interviewed with a standardised questionnaire focusing on asbestos
exposure in the (life-long) residential and occupational
histories and in leisure time activities as well as on occupational
a. |
| The Monfalcone area, in northeastern Italy, is a small industrial
territory (population about 60,000), with a large shipyard.
Between October 1979 and April 1992, ninety-two malignant
mesotheliomas were diagnosed at the Monfalcone Hospital. The
series included 84 men and 8 women, aged 42 to 89 years (median age
68 years). There were 89 pleural and 3 peritoneal
tumors. Seventy patients (69 men and 1 woman) had worked in the
shipyards; six were seamen, and four insulators. Five men
had been exposed to asbestos in various industries; six women had
histories of domestic exposure, and one woman had a
history of possible environmental exposure. The latency periods
(intervals between first exposure to asbestos and diagnosis of
the tumor) ranged from 20 to 65 years (median 52 years). Latency
periods among insulators were significantly lower than
among shipyard workers, as well as lower than among the other
categories (. |
| In order to provide estimates of the accuracy of death certification
of malignant pleural mesothelioma in Italy, the causes of
death of a series of ascertained cases were investigated. The study
included 523 cases of pleural mesothelioma diagnosed in
1984-1988 by 88 hospital departments and clinics. Vital status at 7
May 1990 was ascertained for 92.7% of subjects. The
overall concordance between pathological diagnosis and death
certification was about 75%.
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Med Lav 1994 Mar-Apr;85(2):157-60 |
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