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1/8/2009
Thursday morning
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| The analysis of 335 cases of mesothelioma observed at the Ramazzini
Foundation and the Bologna Institute of Oncology has
shown: 1) a high percentage of correlation of these tumours with
asbestos exposure; 2) a large number of population categories
potentially exposed to asbestos fibres and therefore at risk of
developing mesothelioma; and 3) the high risk of mesothelioma
among people exposed in various circumstances to asbestos used in
railroads and sugar refinery plants.
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Med Lav 1997 Jul-Aug;88(4):316-20 |
| Latency periods (time intervals elapsing between first exposure to
asbestos and death) were examined in 421 cases of
malignant pleural mesothelioma, diagnosed in the Trieste-Monfalcone
area, Italy. Occupational data were collected from the
patients or from their relatives by personal or telephone interviews.
Routine lung sections were examined for asbestos bodies in
370 cases. Latency periods, calculated in 312 cases, ranged from 14
to 72 years (mean 48.7, median 51). Latency periods
differed significantly from one occupational group to another. Mean
latency periods were 29.6 among insulators, 35.4 among
dock workers, 43.7 in a heterogeneous group defined as various, 46.4
in non-shipbuilding industry workers, 49.4 in shipyard
workers, 51.7 among women with a history of domestic exposure to
asbestos, and 56.2 in people employed in maritime
trades. The ANOVA test indicated a correlation between latency
periods an. |
| Our 1990 article reported on recent papers in the peer-reviewed literature and
two international symposia, one at the International Agency for Research on
Cancer (2) and the other at Harvard University (3), all concluding that
chrysotile fibers are less active than amphibole types (crocidolite, amosite,
tremolite) of asbestos in the causation of mesothelioma in man. In his summary
of the IARC meeting, Sir Richard Doll, an eminent epidemiologist, concluded
there is the difference between the effects of chrysotile and amphiboles, which
is so great in relation to mesothelioma that it is possible to argue that
chrysotile does not cause mesothelioma at all (2). This observation has been
supported by numerous peer-reviewed papers and working groups subsequently
(4-6). |
| Mesothelioma, a fatal cancer usually found on the lining of the lung, is
specifically recognized in Ontario—as is asbestosis—as arising from
exposure to asbestos. Mesothelioma is written into the Compensation Act
as a Schedule 4 Disease. |
| A case-control study on pleural malignant mesothelioma (MM) was
conducted in Casale Monferrato, where the largest Italian
asbestos cement (AC) factory had been operating from 1907 to 1985. In
a previous study we observed a five to seven-fold
increase in the incidence of MM among people living in that city and
never employed in the factory mentioned. The present
study includes cases of MM with histological diagnosis over the
period 1.1.1987-30.6.1993 among residents in the Local
Health Unit (LHU) of Casale Monferrato. Population controls were
randomly extracted from the list of the residents in the
LHU, matched to cases on , date of birth, vital status and date of
death. Cases and controls (or their closest relative) were
interviewed with a standardised questionnaire focusing on asbestos
exposure in the (life-long) residential and occupational
histories and in leisure time activities as well as on occupational
a. |
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