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1/8/2009
Thursday morning
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| A spatial cluster of pleural mesothelioma cases was detected in
Broni, in the Province of Pavia (northwestern Italy). Eighteen
deaths due to malignant pleural neoplasms were observed in the years
1980-87 (SMR: 556; 95% confidence interval:
329-878) and the incidence of pleural mesothelioma in 1980-89 was 9.1
cases per 100,000 person-years among men and 4.3
cases among women. These findings are discussed with reference to the
presence in Broni of a plant manufacturing asbestos
cement products.
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| Mr. Bichard finds it hard to contain his anger over his medical problems
and those of colleagues who are dead or are suffering from lung cancer,
brain tumours, or mesothelioma, a rare cancer of the lung lining. |
| Our 1990 article reported on recent papers in the peer-reviewed literature and
two international symposia, one at the International Agency for Research on
Cancer (2) and the other at Harvard University (3), all concluding that
chrysotile fibers are less active than amphibole types (crocidolite, amosite,
tremolite) of asbestos in the causation of mesothelioma in man. In his summary
of the IARC meeting, Sir Richard Doll, an eminent epidemiologist, concluded
there is the difference between the effects of chrysotile and amphiboles, which
is so great in relation to mesothelioma that it is possible to argue that
chrysotile does not cause mesothelioma at all (2). This observation has been
supported by numerous peer-reviewed papers and working groups subsequently
(4-6). |
| Dr. Finkelstein also cited five cases of mesothelioma among former
Holmes workers. Three of the five workers died at less than fifty years
of age and all were less than sixty years old! |
| AIM AND BACKGROUND: To evaluate the characteristics of a case-series
of 79 malignant mesothelioma patients collected
from the main teaching hospital of Rome, Italy, and other local
clinics of Latium Region and to assess the role of asbestos
exposure, since previous studies on the occurrence of the disease in
this area were lacking. METHODS: The study included
cytohistologically diagnosed malignant mesothelioma (71 pleural, 7
peritoneal, and 1 testicular tunica lis) detected or
referred for consultation during the period 1980-1995. Information
regarding occupational and/or nonoccupational exposures
was derived from clinical records and interviews, when available.
RESULTS: Patients were resident in Rome and other towns
of Latium; a few were from other parts of central and southern Italy.
Exposure to asbestos was assessed for 45.5% of patients,
another 45.5% had unknown exposure, and for the remaining 9% such
info. |
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