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1/8/2009
Thursday morning
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| In stating that a threshold of effect has never been found for asbestos, Rall
stands behind the outdated one fiber can kill theory of carcinogenesis.
However, Rall fails to mention data supporting a threshold for chrysotile in
lung cancer (11, asbestosis (12), and mesothelioma (13) as well as a panel
report from the Health Effects Institute-Asbestos Research (HEI-AR) detailing
animal and in vitro dose-response studies exhibiting no-observed adverse effect
levels (NOAELs) for asbestos (14). Our recent work documents a dose-dependent
increase in asbestos-induced proto-oncogene activation in mesothelial cells with
no induction at lowest concentrations of fibers tested and an enhanced potency
of crocidolite asbestos in comparison to chrysotile (15). |
| The Monfalcone area, in northeastern Italy, is a small industrial
territory (population about 60,000), with a large shipyard.
Between October 1979 and April 1992, ninety-two malignant
mesotheliomas were diagnosed at the Monfalcone Hospital. The
series included 84 men and 8 women, aged 42 to 89 years (median age
68 years). There were 89 pleural and 3 peritoneal
tumors. Seventy patients (69 men and 1 woman) had worked in the
shipyards; six were seamen, and four insulators. Five men
had been exposed to asbestos in various industries; six women had
histories of domestic exposure, and one woman had a
history of possible environmental exposure. The latency periods
(intervals between first exposure to asbestos and diagnosis of
the tumor) ranged from 20 to 65 years (median 52 years). Latency
periods among insulators were significantly lower than
among shipyard workers, as well as lower than among the other
categories (. |
| A series of 421 malignant pleural mesotheliomas, diagnosed in the
Trieste-Monfalcone area, northeastern Italy, were reviewed.
A large majority of the patients had been employed in naval work
(shipbuilding, maritime trades, and dock work). Latency
periods (time intervals between first exposure to asbestos and
death), showed wide variations from one occupational category
to another. Such variations were attributable, but only partly, to
differences in the intensity of the exposure to asbestos. Various
family cases were identified, including people with and without blood
relationships. The data, obtained in the studies on
Trieste-Monfalcone mesothelioma, suggest that interactions between
asbestos and other factors play a considerable role in the
pathogenesis of asbestos-related mesothelioma.
___________________________________________________________
Med Lav 1997 Jul-Aug;88(4):310-5 |
| Mr. Bichard finds it hard to contain his anger over his medical problems
and those of colleagues who are dead or are suffering from lung cancer,
brain tumours, or mesothelioma, a rare cancer of the lung lining. |
| A case-control study on pleural malignant mesothelioma (MM) was
conducted in Casale Monferrato, where the largest Italian
asbestos cement (AC) factory had been operating from 1907 to 1985. In
a previous study we observed a five to seven-fold
increase in the incidence of MM among people living in that city and
never employed in the factory mentioned. The present
study includes cases of MM with histological diagnosis over the
period 1.1.1987-30.6.1993 among residents in the Local
Health Unit (LHU) of Casale Monferrato. Population controls were
randomly extracted from the list of the residents in the
LHU, matched to cases on , date of birth, vital status and date of
death. Cases and controls (or their closest relative) were
interviewed with a standardised questionnaire focusing on asbestos
exposure in the (life-long) residential and occupational
histories and in leisure time activities as well as on occupational
a. |
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